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For doses above 0.2 mg, semaglutide resulted in a dose-dependent reduction in HbA1c up to 1.7% (compared to a 0.5% reduction with placebo)

Seeds further noted that we are seeing advancement in GLP-1 receptor agonists going from semaglutide (binds with GLP-1 receptors) to tirzepatide (binds with GLP-1 and GIP receptors) to retatrutide (binds with GLP-1, GIP, and glucagon receptors)

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