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For weekly GLP-1 medications, patients might use the right abdomen one week, left abdomen the next, then alternate thighs, creating a four-week rotation cycle

Manufacturers generally recommend stopping at least two months before trying to conceive

Never skip dose levels entirely

Typical Timeline: First few days: Appetite suppression begins as the medication takes effect Weeks 1-4: Reduced caloric intake leads to initial weight loss Weeks 5-12: Steady weight loss continues, with most patients seeing 5% body weight loss by week 12 3-6 months: Many patients achieve 10% or more total body weight loss Plateau Management: Some patients experience plateaus, which is normal