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Treatment discontinuation due to gastrointestinal side effects occurred in 5.6% of semaglutide users versus 2.7% of tirzepatide users

A double-blind, randomized, placebo-controlled trial employing 227 adults with chronic kidney diseases were taking 25 mg, 75 mg, or 150 mg of bardoxolone methyl every day for a period of 24 weeks or 52 weeks

A First Look at the Numbers A 2026 study published in The Lancet Obstetrics, Gynaecology, and Women's Health took a direct look at this question, evaluating 120 postmenopausal women treated with tirzepatide, one of the most effective GLP-1 and GIP dual receptor agonists currently available [16]

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