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These trials have shown reductions in heart failure symptoms and physical limitations and greater improvement in exercise function and have led to growing interest in new ways to address HFpEF, a condition with limited guideline direct medication therapy compared to heart failure with reduced ejection fraction (HFrEF)

In both cohorts, only 37 individuals originally assigned to the placebo completed it without receiving an active treatment (e.g., orforglipron rescue or other obesity medication), which complicates the interpretation of placebo comparisons after week 24

Semaglutide is not a standalone solution but part of a broader strategy to improve liver function and overall health

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