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Practical support often includes: helping with medication administration reinforcing adherence monitoring for side effects encouraging adequate nutrition and hydration communicating concerns to the healthcare team Because GLP-1 medications can significantly reduce appetite, caregivers can help ensure adequate protein intake and encourage regular, nutrient-dense meals to reduce the risk of malnutrition, muscle loss, and functional decline
Since GLP-1Rs may also signal via Gq or Gi/o, as well as through G protein-independent mechanisms [21-26], further research is needed to determine which signaling molecules other GLP-1R agonists might recruit to activate POMC neurons due to biased agonism
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