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In plain terms, it is interesting because copper is part of the machinery skin and connective tissue use to maintain structure

Disturbances in the intestinal endothelium, lymphoid atrophy, gut dysbiosis, and elevated inflammatory metabolites (TNF, specific pteridines, IL-1, IL-6 and IL-12, fecal calgranulin and myeloperoxidase) further compromise intestinal function [51, 106, 110,111,112] SAM-induced inflammation further inhibits micronutrient uptake, creating a downward spiral in SAM severity and increased morbidity and mortality [104, 113]

And this is just, this is one of the ways that people are trying to look into

J Urol 2006