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Maintaining optimal levels of vitamin B12 and folate is paramount for overall health

It differs from native GLP-2 by a single substitution, alanine to glycine at position 2 , which blocks the DPP-4 enzyme that would otherwise chew the native hormone up within minutes [7]

Thus, in my clinical practice, given the uncertainty about B12 blood levels, if a patient has symptoms suggestive of B12 levels affecting cellular function, unless he/she wishes to undertake further testing with homocysteine and MMA, a trial of sublingual B12 in the active form at 1-2000 mcg daily (to avoid malabsorption issues) is a reasonable course of action

Stress is one of the biggest drivers behind modern cognitive decline