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Chronic hepatitis C infection has been shown to cause mitochondrial GSH depletion [15]

The result is a self-reinforcing cycle: obesity suppresses testosterone, low testosterone promotes further fat accumulation, and the testes receive progressively weaker signals to function

Latter study also identified genes related to iron metabolism (TFRC) and glycolysis (PGK1), in line with VitC-induced changes on the protein level observed in the proteomic studies referred to before [159, 160]