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Product Facts Supplement Facts Serving Size 3 Capsules Servings Per Container 20 Daily Value not established

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Each medication on its own has risks of side effects, and combining the two adds on even more risk

Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30 to 40% without altering the plasma concentrations of its active metabolite, -hydroxymetoprolol