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Other pathogenic species that target TJ protein complexes to disrupt gut barrier integrity include Vibrio cholerae and Aeromonas hydrophila which secrete a hemagglutinin/protease and a pore-forming aerolysin, respectively, facilitating the direct cleavage of occludin (Nava et al

Psoriasis involves uncontrolled activation of T helper cells (Th1) and (Th17), resulting in the overproduction of pro-inflammatory cytokines, such as IL-1, IL-6, IL-23, IL-22, interferon alpha (IFN-), and TNF- (204206)