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The findings of this study suggest long-chain ACs have clinical utility in assessing disease severity in the heart failure population

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This protective effect is mediated through the activation of the Nrf2 signaling pathway, which upregulates antioxidant enzymes such as SOD, CAT, and glutathione peroxidase (GSH-Px), promoting the elimination of ROS and reducing cellular damage (Yuan et al., 2024)