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Severe impairments in electron transport chain (ETC) complex activity are one of the hallmarks of classic mitochondrial diseases
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King K, Lin NP, Cheng YH, Chen GH, Chein RJ
TNF- results in insulin insensitivity, indirectly by stimulating stress hormone production and directly by sustained induction of SOCS-3 which decreases insulin-induced insulin receptor substrate 1 (IRS1) tyrosine phosphorylation and its association with the p85, regulatory subunit of phosphatidylinositol-3 kinase
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