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Some individuals may achieve sufficient lifestyle modification to maintain weight loss without medication, while others may experience weight regain upon discontinuation, necessitating resumed or lifelong therapy

We estimated physiological NADP + and NADPH levels in our healthy cohorts, based on frozen sample results, and validated the theoretical calculation by analyzing fresh whole blood samples from 12 additional healthy volunteers (Supplementary Table 5)

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Examples of laminopathies include EmeryDreifuss muscular dystrophy (EDMD), limb-girdle muscular dystrophy type 1B (LGMD1B) has been reclassified as EDMD2, congenital muscular dystrophy (CMD), dilated cardiomyopathy type 1A, familial partial lipodystrophy type 2, and early aging syndromes such as HutchinsonGilford progeria syndrome 5