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The STEP-HFpEF and STEP-HFpEF DM trials investigated the efficacy of semaglutide (at a dose of 2.4 mg weekly) in patients with obesity-related HFpEF, with and without type 2 diabetes, respectively 28,29

In the SURMOUNT-1 trial, the highest tirzepatide dose produced average weight loss of about 21% over 72 weeks (Source: NEJM, SURMOUNT-1 trial)

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