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Placental transfer of GLP-1 agonists occurs at low levels, but the long-term effects on fetal development, pancreatic function, and metabolic programming remain unstudied

The missed-pill rule (which applies to every GLP-1) Nausea is the most common side effect across the entire GLP-1 class about 1 in 3 patients on Wegovy report it, and rates are higher during the first few weeks and after dose increases

International Journal of Molecular Sciences, 20(21), 5407

These investigations rely on receptor-binding assays, cell-based signaling studies, and glucose regulation models to compare dual agonism with single-receptor GLP-1 agonists