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In most experimental settings, SGLT2i directly reduced inflammation and/or oxidative stress in various cardiac cell types under various pathological conditions such as high-fat diet, hyperglycemia, ischemia/reperfusion, LPS, DOXO, IL-1a/b, TNFa, IL-17a and Ang II

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Desmots F, Rissel M, Gilot D et al (2002) Pro-inflammatory cytokines tumor necrosis factor and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes