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In astudyinvolving rats, BPC-157 was administered in doses of 0, 0.1, 0.25, and 0.5 micrograms/mL over 24 hours. Results showed that the 0.5 microgram/mL dose significantly increased growth hormone expression from day 1 to day 3, while lower doses also had similar effects. The study concluded that BPC-157 supplementation led to increased up-regulation of growth hormone in a dose and time-dependent manner
In hippocampal neurons, CaMK1 is required for NMDA-receptor mediated long-term potentiation, which is a form of synaptic plasticity that is considered a cellular basis of learning and memory formation [100]
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