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TRPV1 is also activated by capsaicin (hot peppers), low extracellular pH, and noxious heat.[ref] TRPA1 is activated by VOCs, cigarette smoke, heavy metals, naphthalene (moth balls), formaldehyde, and styrene.[ref] TRP receptors are highly expressed in the olfactory and trigeminal nerve endings and in the brain

Sandoz CEO Richard Saynor has described Canada as the world's second-largest GLP-1 market, a characterization that is shaping industry expectations as generic semaglutide applications move through Health Canada review [Source: endorhealth.com/article/generic-ozempic-coming-to-canada]