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Added complexity may not yield measurable additional benefit

1 Introduction Ulcerative colitis (UC) is a chronic, relapsing form of inflammatory bowel disease (IBD) characterized by immune system dysfunction and pathological overactivation of mucosal immune responses, leading to persistent inflammation and subsequent colonic mucosal injury (Raine et al., 2022)

In senescent cells, FOXO4 sequesters p53, blocking this process and allowing zombie cells to survive and secrete harmful inflammatory signals known as the Senescence-Associated Secretory Phenotype (SASP)

Frequently Asked Questions What's the difference between AOD-9604 and semaglutide