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discontinuation may result in weight regain unless lifestyle changes are maintained

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However, these trials concentrated on cardiovascular outcomes rather than ocular ones, with inconsistent definitions and grading, rendering them insufficient for evaluating the long-term stabilization or enhancement of retinal pathology following an acute reduction in glycosylated hemoglobin (HbA1c)

Indeed, it has been suggested that agents capable of achieving an average weight reduction of about 15% in individuals with obesity represent a new generation of anti-obesity medications, as this level of weight loss is sufficient to combat or prevent a broader range of obesity-related complications (238)