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Although pathways of de novo lipogenesis and fatty acid oxidation were not significantly enriched in the transcriptomic datasets, qPCR analysis revealed modest but consistent increases in lipogenic genes ( Fasn, Acaca, Elovl6 ) and reductions in fatty acid oxidation genes ( Cpt1a, Acadl ) in GPR146-deficient livers (Supplementary Fig

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MK-677 and Oral Growth Hormone Secretagogues MK-677 (Ibutamoren) is a non-peptide GHS-R1a agonist that shares Ipamorelin's receptor target but is orally bioavailable

Oncology: Evaluates tumor growth and metastasis in preclinical cancer models