(17) Hashimotos is the most common autoimmune condition, but the thyroid gland is not always the weakest link for everyone
Theres strong data on how it works and observational studies support benefits, but some clinical trials show modest or no effects for preventing problems
Cancer has been cured in mice a thousand times over, but diabetes for example is, Type II diabetes is quite predictive, but in terms of nerve crush weve tested this reprogramming effect on human neurons, in the dish at least, and it works effectively to protect those cells, and let them regrow, and make them more youthful
Most common side effect are vomiting & mild anaphylactoid reactions Tx these with reducing rate of infusion and antihistamines Rare severe anaphylactic reaction, tx by usual kitchen sink approach (fluids, stop drug, epi to support hypotension, antihistamines, steroids) Note*** as per Jesse: PO NAC is essentially never used in a Canadian context more of an American thing.Interestingly anaphylactoid reactions are more common in patients with negative acetaminophen levelsSee Table 143.3 for Side effect profile for NAC formulations [7] Describe a NAC protocol for IV administration *** Always check with your local institutions protocol and always call your local tox centre!*** As seen on LITFL: Adult dosing: Give 150 mg/kg NAC diluted in 200 ml of 5% dextrose IV over 15-60 minutes
