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Although description of gonorrhea-like symptoms dates back to ancient civilizations like the Romans, Jews, and Arabs, genomic analysis suggests that the modern gonococcal population originated much more recently, possibly in the 16 th century, and was subsequently spread globally (Golparian et al., 2020)

131 The production of RONS increases the sensitivity of cells to genotoxic drugs by decreasing the activity of DNA-PKcs, hindering repair processes, and leading to the accumulation of DSBs

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Following PH, the reduction in liver mass leads to hormonal changes that shift glucose metabolism towards glycogenolysis and gluconeogenesis in the remnant liver 44 and promote glucose utilization towards the pentose phosphate cycle to provide NADPH for lipid and DNA synthesis 45