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Deficiency Risks and Who Is Most Affected Certain groups are at higher risk of deficiency, including: Vegetarians and vegans Adults over 50 with reduced stomach acid Patients with gut disorders such as Crohns or celiac disease Those taking long-term acid-reducing medications Symptoms of deficiency can include fatigue, pale skin, memory loss, depression, numbness, or tingling sensations

Heart valve lesions in patients treated with appetite suppressants

No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued

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