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In response to physical stimuli, these molecules can initiate signal transduction, modulate the intracellular ion concentration (e.g., calcium, sodium, and chloride), influence cellular tension, volume, and shape, and trigger transcriptional changes, thereby contributing to therapeutic resistance and mediating profound changes in cellular functions, including division, and migration (see sections below)

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Other components including IgA, enzymes, proteins such as lactoferrin and those with antimicrobial properties including bile acids and AMPs, are also present in these mucosal layers and function collectively to restrict the interaction of luminal contents with the epithelial layer (Singh et al

TB-500 is typically once or twice per week during loading