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Tesofensine also increased blood pressure, heart rate, and frequency of mood changes

Some research suggests GIP might influence food reward pathways, but this remains an active area of investigation

Moreover, the risk of heart failure hospitalization was augmented irrespective of age category [84], being highest among patients with elevated levels of natriuretic peptides, previous heart failure, or chronic kidney disease [85]

It also calls constipation one of the most common reasons patients discontinue GLP-1 therapy, which is why it frames the problem as something to plan for with a provider before starting rather than react to later