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Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with type 2 diabetes mellitus and obesity: a randomized dose-ranging study

Glucagon-receptor agonism is the genuinely novel arm: while glucagon classically raises blood glucose, controlled glucagon-receptor activation also increases energy expenditure and drives hepatic fat oxidation, which is why the triple agonist produces such pronounced reductions in liver fat

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The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism