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Weight-Related Health Conditions: Such as hypertension, dyslipidemia, or type 2 diabetes
The reduction in AUC after oral administration can result from numerous mechanisms including: pH or bacterial-mediated metabolism of the drug within the GI tract, incomplete drug absorption from the GI tract, metabolism within the GI epithelium (which contains CYP3A4), excretion back into the GI tract by P-glycoprotein in the GI epithelium, hepatic metabolism, or biliary excretion into the GI tract
That is not enough to establish a reliable consumer timeline, and there is no approved dosing schedule
Second, determining the ideal timing and priority to intensify therapy is also urgently required, since present evidence are not enough to cover this evidence gap
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