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The GIPR arm adds synergistic insulinotropic activity and, in adipose tissue, enhances healthy lipid buffering, reducing ectopic fat deposition in liver and muscle 25

Oxidative stress-induced ROS can activate inflammatory pathways, including NLRP3, ASC, and caspase-1, leading to increased IL-1 expression and inflammation

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Under the deal, Novo Nordisk has secured the exclusive worldwide license to use Ascendis TransCon technology platform to develop, produce, and sell products for metabolic diseases, including obesity and Type 2 diabetes with the primary goal being to develop a monthly GLP-1