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On day 0, animals (n = 3/groups) received a single intravenous (i.v.) dose of MEDI4166 at 1 or 5 mg/kg or a single subcutaneous (s.c.) dose of MEDI4166 at 10 or 100 mg/kg

However, because glucagon-like peptide-1 receptor agonists work to slow gastric emptying, a safety concern has been raised in patients undergoing deep sedation or general anesthesia regarding gastric aspiration, and considering their long half-life in the blood, they are difficult to manage in the perioperative period

Recovery time varies significantly depending on the severity of nerve compression and treatment approach

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