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Emerging microbiome-based therapies, including targeted microbial consortia, engineered probiotics, and metabolite-directed interventions, offer additional options for modulating activity of microbiotagutbrain axis, with ongoing research focusing on personalized treatment strategies and the development of biomarkers for better therapeutic targeting [254,268]

Clinical imaging studies using computed tomography show that GLP-1 receptor agonists preferentially reduce visceral fat volume compared to subcutaneous fat when patients lose weight

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