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& Stylianopoulos, T

SLC7A11 (xCT) With the deepening of ferroptosis research, studies have strengthened the strategy of using the Cystine/Glutamate reverse transporter SLC7A11 (xCT) pathway to regulate ferroptosis, the principle of which is also based on the antioxidant axis system x c - -GSH-GPX4, but the focus falls on the key precursor system of the system x c - (51)

W., Fobbs, W., Robinson, S

Furthermore, the conversion of oxidized glutathione (GSSG) to its reduced form (GSH) by glutathione reductase requires riboflavin in the FAD coenzyme form