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Folic acid is a water-soluble B-type vitamin, which plays a key biological role in many physiological processes, especially in single carbon transfer reactions, nucleic acid synthesis, and methionine regeneration (24, 25)

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Stage IV (also called stage 4) melanoma In stage IV, the cancer has spread to other parts of the body, such as the lung, liver, brain, spinal cord, bone, soft tissue (including muscle), digestive tract, and/or distant lymph nodes

"Gut-brain Axis and migraine headache: a comprehensive review." The Journal of Headache and Pain , 21(1), 1-12