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However, a subsequent study revealed that CTSB contributes not only to the activation of trypsinogen within acinar cells but also within infiltrating macrophages, thereby exacerbating pancreatitis through NF-B nuclear translocation and the production of inflammatory mediators

Wu Y (2024) Efficacy and safety of GLP-1 receptor agonists combined with SGLT-2 inhibitors in elderly patients with type 2 diabetes: a meta-analysis