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Treatment is highly effective: hormone therapy stabilizes the hormonal swings, SSRI/SNRI options help when irritability is severe, and addressing sleep and VMS often improves mood meaningfully without specific mood-targeted treatment

Liver nuclei were isolated using a lysis buffer containing 10mM Tris-Hc pH 7.5, 10mM NaCl2, 3mM MgCl2, 0.05% Triton X, 45uM Actinomycin D, 0.2U/ul SuperaseIn (AM2694, ThermoFisher), and 0.1U/ul RNAse Inhibitor (Y9240L, Qiagen)