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In agreement with the noncompetitive behavior of 9 and as determined by structural superposition of the cryo-EM structure and the X-ray NADPH-TGR- complex 17 , inhibitor 9 does not sterically interfere with NADPH binding

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Peer review Peer review information Nature Metabolism thanks Alice Adriaenssens, Nigel Irwin and the other, anonymous, reviewer(s) for their contribution to the peer review of this work