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Nausea, vomiting, constipation, and gastroparesis symptoms affect 10 to 44% of patients during dose escalation [6]

In the Phase 2 trial, the titration schedule for the 12 mg group looked roughly like this: Weeks 14 at 2 mg, weeks 58 at 4 mg, weeks 912 at 6 mg, weeks 1316 at 8 mg, then 12 mg from week 17 onward

As GEP44 acts directly on muscle tissue, while its effects on islets require concomitant Y1-R antagonism, activation of Y1-R expressed in muscle tissue may ultimately prove to be a critical factor in reducing serum glucose levels, alongside any potential effects on insulin secretion and glucagon release

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