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A 2025 systematic review and meta-analysis of tirzepatide (Masson and colleagues, Reviews in Endocrine and Metabolic Disorders ) found that across seven randomized trials, tirzepatide reduced hsCRP by about 33% and IL-6 by about 18% compared to placebo and the effect held even at the lowest 5 mg dose
However, the active ingredient semaglutide is FDA-approved for weight loss, and compounded semaglutide offers the same clinical benefits as branded alternatives at a lower cost at $189/mo month-to-month, or from $149/mo on the 6-month plan
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