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doi: 10.1111/cmi.12648 118 RamracheyaRDMcCullochLJClarkAWigginsDJohannessenHOlsenMKet al

aeruginosa has been shown to upregulate mucin secretion through the activation of the EGFR pathway by inducing intracellular reactive oxygen species, triggering cytokine production (e.g., IL-1, IL-1, IL-6, IL-8, TNF-), and generating EGFR ligands such as TGF- in epithelial cells (Shao et al., 2003