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Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes

In summary, a large body of research evidence shows that FA synergizes with MSU crystals to induce the initiation of inflammation in GA: FA induces macrophage activation by activating TLR receptors, lysosomal instability/NLRP3, and AMPK/ROS/NLRP3 pathways, while more active FAO promotes the conversion of macrophages to a pro-inflammatory phenotype ( Figure 2 )

These are the real situations people call us in, usually mid-attack, when getting to a clinic is not an option

Just sort of jump in and I think you're right as a clinician, like it's one thing, listen, we've all experimented in ourselves