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72 Addiction Substance use disorders (SUDs) are a major health issue, accounting for 14.5% of disability-adjusted life years according to the Global Burden of Disease Study, 2010

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There is consistent evidence from epidemiologic studies in populations exposed to high arsenic concentrations in drinking water that people who can efficiently convert inorganic arsenic to DMA are at lower risk for arsenic-induced disease than those who are poor methylators, who have higher proportions of MMA and inorganic arsenic in urine