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doi: 10.3389/fphar.2025.1618079 Received 28 April 2025 Accepted 08 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Yang Yang, Chinese PLA General Hospital, China Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2025 Xie, Yang, Tian and Chen

Activation of these receptors may enhance respiratory stability during sleep independent of body weight changes

Folks tend to begin at a lower dose of 2.5 mg per week, then titrate every 4 weeks until they hit their target dose, which may be as high as 15 mg per week

According to NICE guidance (NG136), hypertension is generally diagnosed when clinic blood pressure is 140/90 mmHg and subsequent ambulatory or home blood pressure monitoring confirms readings 135/85 mmHg