Inflammatory Changes Chronic inflammation has been found to be present in all phases of BD (135), since it promotes a pro-inflammatory environment with an increase in cytokine levels, such as IL-1, IL-6, and TNF-, and increased nitric oxide in brain and plasma ( The aforementioned evidence on mitochondrial bioenergetics pathophysiology in mood disorders is summarized in Figure 2, which represents the biphasic mitochondrial model in BD in depression (reduced mitochondrial biogenesis) and mania (increased mitochondrial biogenesis), and the derived biological processes in the mitochondria, including oxidative stress, inflammation, genetic damage, increased permeability, cytotoxicity, and apoptosis
El glutatin es una molcula que el propio cuerpo produce de forma natural
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