6 semaglutide SUSTAIN-6 (NEJM 2016) enrolled 3,297 patients with T2DM at high CV risk and demonstrated that once-weekly reduced 3-point MACE by 26% (HR 0.74; p=0.02), driven by a striking 39% reduction in Heart disease: Semaglutide may reduce

The surge in off-label Ozempic prescriptions has created unprecedented market disruptions, as evidenced by: Dramatic Prescription Shifts : Analysis of prescribing data shows that while over 90% of Ozempic prescriptions in 2018 were for type 2 diabetes, this figure dropped to just 58% by 2023, indicating massive off-label use Celebrity and Social Media Influence : High-profile endorsements from celebrities like Oprah Winfrey, Amy Schumer, and Chelsea Handler sparked unprecedented demand, with the hashtag #Ozempic generating millions of views on TikTok, often downplaying potential gastrointestinal issues associated with the medication Supply Shortages : The surge in off-label prescribing created nationwide drug shortages lasting through 2024, leaving diabetic patients unable to access their prescribed medication Cosmetic Weight Loss Usage : Many new users sought the medication purely for aesthetic weight loss rather than medical necessity, often without meeting clinical criteria for obesity treatment The social media phenomenon surrounding Ozempic fundamentally altered public perception of prescription medications

Supplementation has been shown to reduce the number of Raynauds phenomenon attacks, which are common in lupus

When will TRIUMPH-1 publish

Economic and Outcomes Data Several recent economic analyses illustrate the cost-effectiveness debate over GLP-1s (and by extension the relevance of PA)