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As of February 2026, Eli Lilly plans to submit orforglipron for FDA approval as a diabetes treatment sometime in 2026

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Despite its peptide nature, which often poses bioavailability challenges, Epitalon has been reported in some sources to exhibit resistance to hydrolysis, suggesting potential for oral uptake under specific conditions [1,4, 10]

Table 14: Major Adverse Cardiovascular Events (MACE) by Treatment Group in the SAVOR Trial The Kaplan-Meier-based cumulative event probability is presented in Figure 2 for time to first occurrence of the primary MACE composite endpoint by treatment arm