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"The FDA's Breakthrough Therapy Designation for pemvidutide in MASH reinforces the promise of its clinical profile and potential to address significant unmet needs in this serious, progressive liver disease," said Jerry Durso, President and Chief Executive Officer of Altimmune

The observation that oral versus intravenous glucose administration produced a stronger insulin response is at the core of the incretin effect, defined as the difference in pancreatic -cell insulin secretory response to glucose administered orally or intravenously [21]

In clinical trials, participants who saw the best results with semaglutide also received support to improve their diet and increase their physical activity

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