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Finally, the use of NHANES data spanning three decades (19882018) enabled a longitudinal view of trends in treatment eligibility and benefit

39 MacdonaldJ

Moreover, NADPH binding induced local conformational changes in the N-terminal long loop (residues 3459) of Pa DHDPR, as the His35 and Lys36 residues in this loop interacted with the 2-phosphate group of NADPH, possibly accounting for the strong preference of Pa DHDPR for NADPH