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Clinical trials following patients for 2-3 years show that sustained semaglutide use preserves weight loss, while discontinuation rapidly reverses gains
Devi KP, Rajavel T, Habtemariam S, Nabavi SF, Nabavi SM
Frequently Asked Questions 1Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial New England Journal of Medicine, 2023 2Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1) New England Journal of Medicine, 2021 3Two-Year Effects of Semaglutide in Adults with Overweight or Obesity (STEP 5) Nature Medicine, 2022 4Semaglutide and Cardiovascular Outcomes in Obesity (SELECT trial) New England Journal of Medicine, 2023 5GIP/GLP-1/Glucagon Triple Agonism: Mechanism and Clinical Potential Nature Reviews Endocrinology, 2023 Related Articles Retatrutide Retatrutide Weight Loss: Complete Triple Agonist Guide Semaglutide Semaglutide Dosing Schedule: Complete Week-by-Week Guide Comparison Tirzepatide vs Semaglutide: Which Weight Loss Medication Works Better
It does not elevate cortisol, prolactin, or aldosterone at therapeutic doses
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