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When local L-lactate concentrations persistently exceed physiological thresholds or when D-lactate levels abnormally rise due to methylglyoxal accumulation, and this elevated state persists beyond the acute stress window (Magistretti and Allaman, 2018), excessive histone lactylation modifications evolve from physiological transcriptional fine-tuning into irreversible pathological remodeling

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Open communication is the foundation of this relationship, so never hesitate to ask questions or share concerns about your therapy