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Among the 14 trials included, four excluded patients with heart failure, while the remaining nine articles excluded patients with heart failure, cardiac events (e.g., myocardial infarction, unstable angina, revascularization procedure, stroke) or cardiovascular diseases ( Supplementary Table 4 )

11 In the SUSTAIN-6 trial, semaglutide showed a 26% reduction in MACE, whereas its effects on HF hospitalisation were neutral

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